Targeting early-onset Parkinson’s with AI

It was a source of hard-earned satisfaction after what had often felt like an uphill battle. David Komander and his colleagues had finally published the long-sought structure of PINK1. Mutations in the gene that encodes this protein cause early-onset Parkinson’s, a neurodegenerative disease with a wide range of progressive symptoms – particularly body tremors and difficulty in moving. But when other scientific teams published their own structures for the same protein, it became clear that something was amiss.

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